Escape from X inactivation of two new genes associated with DXS6974E and DXS7020E.

Content Provider	Semantic Scholar
Author	Esposito, Teresa Gianfrancesco, Fernando Ciccodicola, Alfredo D'Esposito, Maurizio Nagaraja, Ramaiah Mazzarella, Richard A. D'Urso, Michele Forabosco, Antonino
Copyright Year	1997
Abstract	Most genes on the X chromosome undergo "inactivation," being transcribed from only one copy in female somatic cells, but several human genes have been shown to be expressed from both the active and the otherwise inactivated homologue. To assess further the fraction and location of genes that escape inactivation, we have analyzed the inactivation status of a set of 73 expressed sequence tags that were derived from the sequencing of cDNA collections and mapped to the X chromosome. Of 33 that were expressed in cultured cells, as assessed by reverse transcription and PCR, 4 (about 12%) were transcribed from both the active and the inactive X chromosome. Two, RPS4 and PCTAIRE1, are already known to escape inactivation; the other 2, of unknown function, include a short cDNA with a full open reading frame and a transcript with no detectable open reading frame. They map, respectively, to Xp11.3-p11.4 and Xp22.2; both regions were previously reported to encode sequences transcribed from the inactive X. Neither transcript has a corresponding sequence on the Y. Thus, they exhibit double dosage in females compared to males, and inactivation status may be inconsequential for these transcribed sequences.
Starting Page	1862
Ending Page	1867
Page Count	6
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://rich-mazzarella.net/genomics97d.pdf
PubMed reference number	9244435v1
Volume Number	43
Issue Number	2
Journal	Genomics
Language	English
Access Restriction	Open
Subject Keyword	Biopolymer Sequencing CDK16 wt Allele Collections (publication) Congenital chromosomal disease DNA, Complementary Diploid Cell Homologous Gene Inactive - Biochemical Activity Level Open Reading Frames Physical Inactivity Pierre Robin Syndrome RPS4X gene Reading Frames (Nucleotide Sequence) Reverse Transcription Transcript X Chromosome Inactivation function Xp22.2
Content Type	Text
Resource Type	Article