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Neural pathways mediating the inhibition of shivering by nonthermal afferent impulses from ischemic limbs
| Content Provider | Semantic Scholar |
|---|---|
| Author | Stoner, Harry Berrington Marshall, Hiram W. |
| Copyright Year | 1982 |
| Abstract | Abstract Hind-limb tourniquet ischemia in the rat inhibits thermoregulatory shivering, lowering the ambient temperature at which it commences. This effect was prevented by the injection of 0.5% bupivacaine into the nerve trunks of the hind limbs and around the base of the thighs before the application of the tourniquets and also by lesions in the ventrolateral part of the spinal cord. The effect was also prevented by infiltrating the tissues distal to the tourniquets with 0.5% bupivacaine 15 min after their application. This was not effective if delayed until 105 min after application. We conclude that the afferent impulses that produce this effect ascend in the same part of the spinal cord as those concerned in neuroendocrine responses to trauma. Other effects of tourniquets on the responses to lowering the ambient temperature, i.e., the reduction in slope of the regression line realting the intensity of shivering to ambient temperature and the reduction in the increase in colon temperature, were not corrected by any of these procedures. |
| Starting Page | 275 |
| Ending Page | 284 |
| Page Count | 10 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0014-4886(82)90046-2 |
| PubMed reference number | 7140897 |
| Journal | Medline |
| Volume Number | 78 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0014488682900462 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0014488682900462?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0014-4886%2882%2990046-2 |
| Journal | Experimental Neurology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
