Pentylenetetrazol: Posttraining injection facilitates discrimination learning in rhesus monkeys

Content Provider	Semantic Scholar
Author	Bowman, Robert E. Heironimus, Mark P. Harlow, Harry Frederick
Copyright Year	1979
Abstract	Rhesus monkeys (Macaca mulatta) given immediate posttraining injections of pentylenetetrazol (PTZ) exhibited improved acquisition of difficult discrimination-learning problems (Experiment 2) but not of easy problems (Experiment 1). Optimal facilitation occurred at a dosage of 10 mg/kg. In two further experiments, the interval between training and the injection of 10 mg/kg of PTZ was varied and optimal facilitation occurred at the 15-min interval. At the 30-min interval, facilitation was absent and error rates were as high as the saline controls, but at the 60-min interval a lower error rate was again seen. All findings were remarkably similar to those previously reported in mice, suggesting a common mechanism for the effect of PTZ on simple discrimination learning in both species. Through the use of the monkey, the potential enhancement of more complex learning by drugs is now accessible to investigation.
Starting Page	265
Ending Page	268
Page Count	4
File Format	PDF HTM / HTML
DOI	10.3758/BF03326638
Volume Number	7
Alternate Webpage(s)	https://rd.springer.com/content/pdf/10.3758%2FBF03326638.pdf
Alternate Webpage(s)	https://doi.org/10.3758/BF03326638
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article