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Immune responses against human papillomavirus (HPV) type 16 virus-like particles in a cohort study of women with cervical intraepithelial neoplasia. II. Systemic but not local IgA responses correlate with clearance of HPV-16.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Bontkes, Hetty J. Gruijl, Tanja D. De Walboomers, Jan M. M. Schiller, John T. Dillner, Joakim Helmerhorst, T. J. Verheijen, René H. M. Scheper, Rik J. Meijer, Chris J. L. M. |
| Copyright Year | 1999 |
| Abstract | To investigate whether there is an association between local or systemic IgG and IgA responses against human papillomavirus (HPV) type 16 virus-like particles (VLP) containing L1 and L2 and the possible influence of these responses on clearance of HPV-16 and its associated lesions, cervical mucus samples from 125 patients and plasma samples from 100 patients, all participating in a non-intervention cohort study of women with abnormal cytology, were analysed. The results show that local IgG and IgA HPV-16 VLP-specific antibodies do not correlate with virus clearance. However, systemic IgG responses were more frequently detected in patients with a persistent infection (11/24) compared with patients with cleared HPV-16 infections (3/28, P = 0.006). Furthermore, the ultimate development of high-grade lesions was associated with systemic VLP-specific IgG reactivity (P = 0.026). By contrast, systemic IgA responses were correlated with virus clearance (7/28 clearance compared with 1/24 persistence patients, P = 0.06). This correlation was statistically significant when only those clearance patients who tested HPV-16 DNA-positive at more than one visit were included in the analysis (5/11 compared with 1/24, P = 0.007). As these systemic IgA responses were not accompanied by local IgA responses, the systemic IgA responses in HPV-16 clearance patients are suggested to be a by-product of a successful cellular immune response induced at the local lymph nodes, mediated by cytokines. |
| Starting Page | 1 |
| Ending Page | 6 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.microbiologyresearch.org/docserver/fulltext/jgv/80/2/0800409a.pdf?accname=guest&checksum=97A3A07600471029701EAB3A5F97B114&expires=1544039278&id=id |
| Alternate Webpage(s) | http://www.microbiologyresearch.org/docserver/fulltext/jgv/80/2/0800409a.pdf?accname=guest&checksum=81AA7231893C56CA1DD4F4E6A6473843&expires=1539652154&id=id |
| PubMed reference number | 10073701v1 |
| Volume Number | 80 |
| Part | 2 |
| Journal | The Journal of general virology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
