NDLI: Prominent role of histone lysine demethylases in cancer epigenetics and therapy

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Prominent role of histone lysine demethylases in cancer epigenetics and therapy

Content Provider	Semantic Scholar
Author	Janardhan, Avilala Kathera, Chandrasekhar Darsi, Amrutha Ali, Wajid He, Lingfeng Yang, Yanhua Luo, Libo Guo, Zhigang
Copyright Year	2018
Abstract	Protein methylation has an important role in the regulation of chromatin, gene expression and regulation. The protein methyl transferases are genetically altered in various human cancers. The enzymes that remove histone methylation have led to increased awareness of protein interactions as potential drug targets. Specifically, Lysine Specific Demethylases (LSD) removes methylated histone H3 lysine 4 (H3K4) and H3 lysine 9 (H3K9) through formaldehyde-generating oxidation. It has been reported that LSD1 and its downstream targets are involved in tumor-cell growth and metastasis. Functional studies of LSD1 indicate that it regulates activation and inhibition of gene transcription in the nucleus. Here we made a discussion about the summary of histone lysine demethylase and their functions in various human cancers.
Starting Page	34429
Ending Page	34448
Page Count	20
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.oncotarget.com/index.php?journal=oncotarget&op=download&page=article&path%5B%5D=24319&path%5B%5D=76398
PubMed reference number	6188137
Alternate Webpage(s)	https://doi.org/10.18632/oncotarget.24319
DOI	10.18632/oncotarget.24319
Journal	Oncotarget
Volume Number	9
Language	English
Access Restriction	Open
Subject Keyword	Cell Nucleus Drug Delivery Systems Epigenetic Process Formaldehyde Gene Expression Histone H3 Lysine 4 Histone H3 Lysine 9 Histones KDM1A wt Allele Neoplasms Transcription, Genetic Transferase cell growth lysine 6-aminotransferase oxidation study of epigenetics
Content Type	Text
Resource Type	Article

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