NDLI: Protein phosphatase 4 interacts with the Survival of Motor Neurons complex and enhances the temporal localisation of snRNPs.

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Protein phosphatase 4 interacts with the Survival of Motor Neurons complex and enhances the temporal localisation of snRNPs.

Content Provider	Semantic Scholar
Author	Carnegie, Graeme K. Sleeman, Judith E. Morrice, Nick Hastie, Charles James Peggie, Mark Philp, Amanda Lamond, Angus I. Cohen, Patricia T. W.
Copyright Year	2003
Abstract	Protein phosphatase 4 (PPP4) is a ubiquitous essential protein serine/threonine phosphatase found in higher eukaryotes. Coordinate variation of the levels of the catalytic subunit (PPP4c) and the regulatory subunit (R2) suggests that PPP4c and R2 form a heterodimeric core to which other regulatory subunits bind. Two proteins that specifically co-purify with Flag-epitope-tagged R2 expressed in HEK-293 cells were identified as Gemin3 and Gemin4. These two proteins have been identified previously as components of the Survival of Motor Neurons (SMN) protein complex, which is functionally defective in the hereditary disorder spinal muscular atrophy. Immuno-sedimentation of the epitope-tagged SMN protein complex from HeLa cells expressing CFP-SMN showed that the SMN protein interacts, as previously reported, with Gemin2 (SIP1), Gemin3 and Gemin4 and in addition associates with PPP4c. The SMN complex has been implicated in the assembly and maturation of small nuclear ribonucleoproteins (snRNPs). Expression of GFP-R2-PPP4c in HeLa cells enhances the temporal localisation of newly formed snRNPs, which is consistent with an association of R2-PPP4c with the SMN protein complex.
Starting Page	393
Ending Page	400
Page Count	8
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://jcs.biologists.org/content/joces/early/2003/03/18/jcs.00409.full.pdf
Alternate Webpage(s)	http://www.trinklelab.com/pubpdf/03/jcs03pp4.pdf
Alternate Webpage(s)	http://jcs.biologists.org/content/joces/116/10/1905.full.pdf
PubMed reference number	12668731v1
Volume Number	116
Part	10
Journal	Journal of cell science
Language	English
Access Restriction	Open
Subject Keyword	Biologic Development CFP gene Catalytic Domain Epilepsy, Partial, Motor GEMIN2 gene GEMIN4 gene Green Fluorescent Proteins Hereditary Diseases Juvenile Spinal Muscular Atrophy Muscle PPP4C gene Protein Serine/Threonine Phosphatase Protein phosphatase SLC9A3R2 gene SMN Complex Small Nuclear Ribonucleoproteins Threonine Tracer establishment and maintenance of localization primary motor cortex
Content Type	Text
Resource Type	Article

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Gemin4 is an essential gene in mice, and its overexpression in human cells causes relocalization of the SMN complex to the nucleoplasm

Protein phosphatase 4 interacts with the Survival of Motor Neurons complex and enhances the temporal localisation of snRNPs.

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Protein phosphatase 4 interacts with the Survival of Motor Neurons complex and enhances the temporal localisation of snRNPs.

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