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MK-801 is a potent nematocidal agent. Characterization of MK-801 binding sites in Caenorhabditis elegans.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Schaeffer, James M. Bergstrom, Ami Turner, Mervyn J. |
| Copyright Year | 1989 |
| Abstract | MK-801, an N-methyl-D-aspartate antagonist in mammalian brain tissue, is a potent nematocidal agent. Specific MK-801 binding sites have been identified and characterized in a membrane fraction prepared from the free-living nematode Caenorhabditis elegans. The high-affinity MK-801 binding site has an apparent dissociation constant, Kd, of 225 nM. Unlike the MK-801 binding site in mammalian tissues, the C. elegans binding site is not effected by glutamate or glycine, and polyamines are potent inhibitors of specific MK-801 binding. |
| Starting Page | 1825 |
| Ending Page | 1829 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.biochemj.org/content/ppbiochemj/260/3/923.full.pdf |
| PubMed reference number | 2669739v1 |
| Volume Number | 260 |
| Issue Number | 3 |
| Journal | The Biochemical journal |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Aspartic Acid Binding Sites Body tissue Caenorhabditis elegans Dizocilpine Maleate Glutamic Acid Glycine Mammals N-Methylaspartate Nematodes Polyamines Tissue membrane |
| Content Type | Text |
| Resource Type | Article |
