The NMDA receptor antagonist MK-801 has a dissociative effect on seizure activity of hippocampal-kindled cats

Content Provider	Semantic Scholar
Author	Wada, Yuji Hasegawa, Hidehiro Nakamura, Mitsuhiko Yamaguchi, Nariyoshi
Copyright Year	1992
Abstract	This study assessed the behavioral and electrographic effects of (+)-5-methyl-10,11-dihydro-5H-dibenzo-[a,d]cyclohepten-5,10-imine maleate (MK-801) (0.1 and 0.5 mg/kg, IP), a noncompetitive antagonist of the NMDA receptors, in hippocampal (HIP)-kindled cats. MK-801 at a higher dose significantly reduced the afterdischarge duration, but not the behavioral seizure stage, of HIP-kindled seizures. This anticonvulsant effect occurred in association with the appearance of severe behavioral toxicity and paradoxical worsening of background electroencephalogram characterized by profound spike and wave discharges. The present data suggest the dissociative effect of MK-801 on seizure activity and limitations of its clinical utility as an antiepileptic agent.
Starting Page	1269
Ending Page	1272
Page Count	4
File Format	PDF HTM / HTML
DOI	10.1016/0091-3057(92)90513-F
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/009130579290513F
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/009130579290513F?dgcid=api_sd_search-api-endpoint
PubMed reference number	1475311
Alternate Webpage(s)	https://doi.org/10.1016/0091-3057%2892%2990513-F
Journal	Medline
Volume Number	43
Journal	Pharmacology Biochemistry and Behavior
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article