NDLI: Identification and modulation of a naturally processed T cell epitope from the diabetes-associated autoantigen human glutamic acid decarboxylase 65 (hGAD65).

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Identification and modulation of a naturally processed T cell epitope from the diabetes-associated autoantigen human glutamic acid decarboxylase 65 (hGAD65).

Content Provider	Semantic Scholar
Author	Nepom, Gerald T. Lippolis, John D. White, Forest M. Masewicz, Susan A. Marto, Jarrod A. Herman, Andrew Luckey, Chance John Falk, Ben A. Shabanowitz, Jeffrey Hunt, Donald F. Engelhard, Victor H. Nepom, Barbara S.
Copyright Year	2001
Abstract	T cell recognition of autoantigens is critical to progressive immune-mediated destruction of islet cells, which leads to autoimmune diabetes. We identified a naturally presented autoantigen from the human islet antigen glutamic acid decarboxylase, 65-kDa isoform (GAD65), by using a combination of chromatography and mass spectrometry of peptides bound by the type I diabetes (insulin-dependent diabetes mellitus, IDDM)-associated HLA-DR4 molecule. Peptides encompassing this epitope-stimulated GAD65-specific T cells from diabetic patients and a DR4-positive individual at high risk for developing IDDM. T cell responses were antagonized by altered peptide ligands containing single amino acid modifications. This direct identification and manipulation of GAD65 epitope recognition provides an approach toward dissection of the complex CD4(+) T cell response in IDDM.
Starting Page	1323
Ending Page	1326
Page Count	4
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.pnas.org/content/98/4/1763.full.pdf
PubMed reference number	11172025v1
Volume Number	98
Issue Number	4
Journal	Proceedings of the National Academy of Sciences of the United States of America
Language	English
Access Restriction	Open
Subject Keyword	Amino Acids Autoantigens Carboxy-Lyases Chronic Lymphocytic Leukemia Diabetes Mellitus Diabetes Mellitus, Insulin-Dependent Diabetes, Autoimmune Glutamate Decarboxylase Glutamic Acid Decarboxylase 2 Measurement HLA-DQ Antigens Islets of Langerhans Leukemia, B-Cell Ligands Patients Spectrometry T-Lymphocyte Thioctic Acid
Content Type	Text
Resource Type	Article

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