NDLI: Dietary monounsaturated fatty acids enhance cholesterol efflux from human fibroblasts. Relation to fluidity, phospholipid fatty acid composition, overall composition, and size of HDL3.

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Dietary monounsaturated fatty acids enhance cholesterol efflux from human fibroblasts. Relation to fluidity, phospholipid fatty acid composition, overall composition, and size of HDL3.

Content Provider	Semantic Scholar
Author	Sola, R. Motta, Clio Bertelli Maillé, Michel Bargalló, M. T. Boisnier, C. Richard, Jessica Jacotot, Bernard
Copyright Year	1993
Abstract	This study was designed to determine whether modifications induced by dietary fats on the high-density lipoprotein3 (HDL3) physicochemical characteristics could affect cholesterol efflux and intracellular cholesterol content, leading to upregulation of low-density lipoprotein (LDL) receptor activity from cultured fibroblasts. Serum HDL3S were obtained from 12 healthy women aged 26 to 49 years who adhered to four 7-week isocaloric diets containing 30% of the caloric intake as fat. Of the total calories, 15.6% of each diet was provided by (1) milk fats, rich in saturated fatty acids; (2) sunflower oil, rich in n-6 polyunsaturated fatty acids; (3) olive oil, rich in monounsaturated fatty acids; and (4) rapeseed oil, rich in n-3 polyunsaturated fatty acids. HDL3 isolated after the monounsaturated fatty acid diet induced the greatest cellular [3H]free cholesterol efflux, reduced the content of intracellular cholesterol, and enhanced 125I-LDL degradation. Univariate regression analyses suggested that the increased capacity of HDL3 to promote cellular [3H]free cholesterol efflux was in part due to its greater fluidity, higher cholesteryl ester content, elevated linoleic to linolenic acid ratio in phospholipids, and its smaller size. In conclusion dietary fats induced physicochemical changes in HDL3, which strongly modulated cellular cholesterol homeostasis in vitro. These data also suggest a novel mechanism by which dietary fats exert their effect on atherosclerosis.
File Format	PDF HTM / HTML
DOI	10.1161/01.ATV.13.7.958
PubMed reference number	8318513
Journal	Medline
Volume Number	13
Issue Number	7
Alternate Webpage(s)	http://atvb.ahajournals.org/content/atvbaha/13/7.toc.pdf
Alternate Webpage(s)	https://doi.org/10.1161/01.ATV.13.7.958
Journal	Arteriosclerosis and thrombosis : a journal of vascular biology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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