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Hypoxia-ischemia produces focal disruption of glutamate receptors in developing brain.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Silverstein, Faye Sarah Torke, L. Barks, J. H. Johnston, Michael V. |
| Copyright Year | 1987 |
| Abstract | We examined the impact of a perinatal hypoxic-ischemic insult on the distribution of glutamate receptors in developing brain. We used a well characterized rodent model for perinatal hypoxic-ischemic encephalopathy, unilateral carotid artery occlusion followed by exposure to 8% oxygen for 2.5 h in 7-day-old rat pups. This preparation results in focal neuronal damage in striatum, hippocampus, and cortex ipsilateral to ligation. Alterations in the regional distribution of glutamate binding in the first 24 h after the insult were assessed with quantitative in vitro [3H]glutamate autoradiography. In lesioned animals, we found progressive selective reductions in [3H]glutamate binding in forebrain ipsilateral to ligation in regions destined for neuronal damage. The earliest and most prominent unilateral reductions in binding were noted in the dentate gyrus of hippocampus (-45 +/- 9%, compared with contralateral hemisphere at 24 h). Acute reductions in specific glutamate binding appear to be a sensitive marker for hypoxic-ischemic neuronal damage in the immature brain. These observations suggest that neurons bearing glutamate receptors may be particularly susceptible to hypoxic-ischemic injury. |
| Starting Page | 37 |
| Ending Page | 67 |
| Page Count | 31 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://deepblue.lib.umich.edu/bitstream/handle/2027.42/26646/0000188.pdf?isAllowed=y&sequence=1 |
| Alternate Webpage(s) | https://deepblue.lib.umich.edu/bitstream/handle/2027.42/26646/0000188.pdf?sequence=1 |
| PubMed reference number | 2887258v1 |
| Volume Number | 431 |
| Issue Number | 1 |
| Journal | Brain research |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Anoxia Autoradiography Brain Diseases Brain Ischemia Carotid Arteries Carotid artery occlusion Glutamate Receptor Glutamic Acid Hypoxia Hypoxic Brain Damage Hypoxic-Ischemic Encephalopathy In Vitro [Publication Type] Ligation Neostriatum Nerve Degeneration Occlusion of artery (disorder) Oxygen Prosencephalon Structure of dentate gyrus |
| Content Type | Text |
| Resource Type | Article |
