NDLI: Small Cell Lung Cancer Accompanied by Tonsillar Metastasis and Anti-Hu Antibody-Associated Paraneoplastic Neuropathy

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Small Cell Lung Cancer Accompanied by Tonsillar Metastasis and Anti-Hu Antibody-Associated Paraneoplastic Neuropathy

Content Provider	Semantic Scholar
Author	Ni, Jianjiao Weng, Linqian Liu, Ming-Sheng Yang, Hua Wang, Yingyi
Copyright Year	2015
Abstract	AbstractTonsillar metastatic small cell lung cancer (SCLC) is rare, while anti-Hu antibodies are frequently found in SCLC.A 66-year-old man was admitted to our hospital with painful dysesthesia and muscle weakness in the distal extremities for over 1 year, progressive dysphagia for over 1 month, and severe cough and dyspnea for over 1 week. He was diagnosed with SCLC accompanied by tonsillar metastasis and anti-Hu antibody-associated paraneoplastic sensory neuropathy (PSN). The patient tolerated 6 cycles of sequential chemoradiotherapy and gradually recovered. The patient's disease remained in remission 2 years after the diagnosis with a remarkable reduction of tumor burden and a persisting high titer of anti-Hu antibodies. To our knowledge, this is the first case of tonsillar metastatic SCLC accompanied by anti-Hu antibody-associated PSN, whereby the anticancer immune response was presumed to play a vital role in disease control.Unilateral tonsillar metastasis of SCLC accompanied by anti-Hu antibody-associated PSN can occur and in certain circumstances, may have a favorable prognosis.
File Format	PDF HTM / HTML
DOI	10.1097/MD.0000000000002291
Alternate Webpage(s)	https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d1/ff/medi-94-e2291.PMC5058936.pdf
PubMed reference number	26683964
Alternate Webpage(s)	https://doi.org/10.1097/MD.0000000000002291
Journal	Medline
Volume Number	94
Journal	Medicine
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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