Antigenic variation of Foot and Mouth Disease Virus-An Overview

Content Provider	Semantic Scholar
Author	Longjam, Neeta Tayo, Tilling
Copyright Year	2011
Abstract	Foot and mouth disease (FMD) is a highly contagious viral diseases of cloven-hoofed animals, caused by FMD virus, a single molecule of linear positive sense, with single stranded RNA of size 7.2– 8.4 kb. Antigenic variation is one of the striking characters of FMD virus. It is a process by which an infectious organism alters its surface proteins in order to evade a host immune response and is associated with mutation leading to amino acid replacement. These changes may result either in the field or in the laboratory leading to the development of a new strain of virus which totally differs from the circulating field strain challenging the vaccine strains use for controlling the diseases. The high sequence variability found in VP1 region of this virus accounts for the low cross-reactivity observed among different serotypes of FMDV and also due to high degree of antigenic variation may be attributed to different reasons like high rate of mutation, genetic recombination, quasispecies nature of the virus and continuous circulation of the virus in the field, which is a main loophole for severe economic loss in livestock productions.
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Alternate Webpage(s)	http://www.veterinaryworld.org/Vol.4/October%20-%202011/Antigenic%20variation%20of%20Foot%20and%20Mouth%20Disease%20Virus%20-%20An%20Overview.pdf
Language	English
Access Restriction	Open
Subject Keyword	Amino Acids Antigenic Variation Computer virus Foot-and-Mouth Disease Virus Hereditary Diseases Livestock Mouth Diseases Mutation Parkinson Disease RNA Sensorineural Hearing Loss (disorder) Serotype Spatial variability Virus Diseases
Content Type	Text
Resource Type	Article