NDLI: Synthesis and controlled-release properties of chitosan/β-Lactoglobulin nanoparticles as carriers for oral administration of epigallocatechin gallate

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Synthesis and controlled-release properties of chitosan/β-Lactoglobulin nanoparticles as carriers for oral administration of epigallocatechin gallate

Content Provider	Semantic Scholar
Author	Liang, Jin Hua Yang, Han-Joo Wan, Xiaochun Lee, Jason Wan Leong Ko, Sanghoon
Copyright Year	2016
Abstract	A nano-sized double-walled carrier composed of chitosan and β-lactoglobulin (β-Lg) for oral administration of epigallocatechin gallate (EGCG) was developed to achieve a prolonged release of EGCG in the gastrointestinal tract. Carboxymethyl chitosan (CMC) solution was added dropwise to chitosan hydrochloride (CHC) containing EGCG to form a primary coating by ionic complexation. Subsequently, β-Lg was added to create a secondary layer by ionic gelation. The obtained EGCG-loaded chitosan/β-Lg nanoparticles had sizes between 100 and 500 nm and zeta potentials ranging from 10 to 35mV. FT-IR spectroscopy revealed a high number of hydrogen-bonding sites in the nanoparticles, which could incorporate EGCG, resulting in high encapsulation efficiency. EGCG incorporated in the primary coating was released slowly over time by diffusion from the swollen CMC-CHC matrix after the outer layer of β-Lg was degraded in the intestinal fluid. The sustained-release property makes chitosan/β-Lg nanoparticles an attractive candidate for effective delivery of EGCG.
Starting Page	1583
Ending Page	1590
Page Count	8
File Format	PDF HTM / HTML
DOI	10.1007/s10068-016-0244-y
PubMed reference number	30263448
Journal	Medline
Volume Number	25
Alternate Webpage(s)	http://dasan.sejong.ac.kr/~sko/paper/2016%20Synthesis%20and%20controlled-release%20properties%20of%20chitosan%20beta-Lactoglobulin%20nanoparticles%20as%20carriers%20for%20oral%20administration%20of%20epigallocatechin%20gallate.pdf
Alternate Webpage(s)	https://doi.org/10.1007/s10068-016-0244-y
Journal	Food Science and Biotechnology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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