Loading...
Please wait, while we are loading the content...
Similar Documents
Endocannabinoid system--a novel target for cardiometabolic risk.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Joshi, Shashank R. |
| Copyright Year | 2007 |
| Abstract | The endocannabinoid system (EC) plays a significant role in appetite drive and associated behaviours. Therefore attenuation of the activity of the EC system would have therapeutic benefit in treating disorders that might have a component of excess appetite drive or over-activity of the endocannabinoid system, such as obesity, ethanol and other drug abuse, and a variety of central nervous system and other disorders. Antagonists of cannabinoid receptors have been designed through rational drug discovery essential to exploit these novel targets for potential in obesity, metabolism, addiction, pain and neurologic disorders. Rimonabant is the only compound in this group which along this pathway is now approved as a selective CB (1) (cannabinoid receptor subtype 1) antagonist, or inverse agonist, in the European Union and India and under regulatory review in the United States for the treatment of obesity and associated cardiometabolic risk. |
| File Format | PDF HTM / HTML |
| PubMed reference number | 17879500 |
| Journal | Medline |
| Volume Number | 55 |
| Alternate Webpage(s) | http://www.japi.org/june2007/R-439.pdf |
| Journal | The Journal of the Association of Physicians of India |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
