Modulation of N-methyl-d-aspartate receptor mediated arachidonic acid release by endogenous nitric oxide in cultured neurons

Content Provider	Semantic Scholar
Author	Rodríguez-Álvarez, José Blanco, Isaac Patel, Ambrish J.
Copyright Year	1996
Abstract	Nitric oxide (NO) and arachidonic acid (AA) are believed to act as intra- and intercellular messengers in the central nervous system. Using primary cultures of striatal and hippocampal neurons, we have studied the effect of endogenous NO on N-methyl-D-aspartate (NMDA)-mediated AA release. Inhibition of NO synthesis with L-NG-nitroarginine (L-Noarg) produced a dose-dependent increase in NMDA-mediated AA release that was reversed by L-arginine. On the other hand, L-Noarg did not modify AA release produced by joint stimulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and phospholipase C-coupled metabotropic subtypes of glutamate receptors. Our results indicate that endogenously produced NO could modulate cellular events mediated by NMDA-induced AA release.
Starting Page	95
Ending Page	98
Page Count	4
File Format	PDF HTM / HTML
DOI	10.1016/S0304-3940(96)13119-0
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0304394096131190
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0304394096131190?dgcid=api_sd_search-api-endpoint
PubMed reference number	8945736
Alternate Webpage(s)	https://doi.org/10.1016/S0304-3940%2896%2913119-0
Journal	Medline
Volume Number	218
Journal	Neuroscience Letters
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article