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Early detection of interstitial lung disease in asbestos exposed non-smoking workers by mid-expiratory flow rate and high resolution computed tomography.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Dujic, Zeljko Tocilj, Jadranka Sarić, Marko |
| Copyright Year | 1991 |
| Abstract | Ten years of lung function and radiological findings in six non-smoking asbestos exposed subjects who had increased mid-expiratory flow rate (FEF 25-75%) as the only functional abnormality were prospectively analysed. A biphasic change in FEF25-75% was noted. It initially increased up to the fifth year, and then a decrease was seen. In the final three years of the study, FEF25-75% reduction correlated well with a decrease in pulmonary capacity for CO (DLCO). During that time high resolution computed tomography (HRCT) probability scores correlated inversely with FEF25-75% and with DLCO, whereas chest radiography was unchanged (International Labour Organisation (ILO) profusion below 1/1). For five of the six subjects HRCT probability of asbestosis was intermediate. An increase in FEF25-75% in some asbestos exposed non-smoking workers may be one of the earliest functional signs indicative of future development of parenchymal asbestosis. Early asbestos related parenchymal abnormalities are seen more frequently on HRCT than on chest radiography. |
| Starting Page | 47 |
| Ending Page | 62 |
| Page Count | 16 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://oem.bmj.com/content/oemed/48/10/663.full.pdf |
| PubMed reference number | 1657109v1 |
| Volume Number | 48 |
| Issue Number | 10 |
| Journal | British journal of industrial medicine |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Asbestos Asbestosis Carbon Monoxide Diffusing Capability Test Congenital Abnormality Congenital neurologic anomalies Diagnostic radiologic examination Expiration, function High Resolution Computed Tomography Labor (Childbirth) Lung Diseases, Interstitial Lung diseases Plain chest X-ray Radiographic imaging procedure Respiratory physiology Smoke adult pineal parenchymal tumor |
| Content Type | Text |
| Resource Type | Article |