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Betapapillomaviruses in the anal canal of HIV positive and HIV negative men who have sex with men
| Content Provider | Semantic Scholar |
|---|---|
| Author | Poljak, Mario Kocjan, Boštjan J. Mlakar, Boštjan Hošnjak, Lea Komloš, Kristina Fujs Milosevic, Milos Seme, Katja |
| Copyright Year | 2014 |
| Abstract | BACKGROUND Betapapillomaviruses (β-PV) are etiologically associated with epidermodysplasia verruciformis and a proportion of skin precancerous lesions and cancer, mainly in immunocompromised individuals. OBJECTIVES The prevalence and persistence of anal β-PV infection and β-PV type distribution were determined in a cohort of men who have sex with men (MSM). A correlation with HIV-1 infection status and selected demographic and behavioral risk factors were additionally established. STUDY DESIGN A total of 181 anal swabs (135 initial and 46 follow-up swabs) obtained from 135 Slovenian MSMs (17.0% HIV-1 positive) were tested for the presence of 25 different β-PV types using Diassay RHA Kit Skin (beta) HPV assay and, if negative, with an in-house nested M(a)/H(a) PCR. RESULTS β-PVs were detected in 88/135 (65.2%) initial anal swabs. Infection with multiple β-PV types was found in 26 samples; the number of β-PVs ranged from 2 to 9. A total of 29 distinct β-PVs were detected: HPV-36 and HPV-38 were the most prevalent, followed by HPV-23, HPV-24, and HPV-93. HIV-1 positive status, promiscuity and use of alkyl nitrites were significantly associated with a higher prevalence of anal β-PV infection. Three partial DNA sequences suggesting putative new HPV types were identified. CONCLUSION To the best of our knowledge, this is the first study to investigate and characterize β-PV infections in the anal region. We showed that anal β-PV infection is highly prevalent in the MSM population and that β-PVs can establish persistent infection in the anal region for up to 4.8 years. |
| Starting Page | O13 |
| Ending Page | O13 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.jcv.2014.07.009 |
| PubMed reference number | 25097015 |
| Journal | Medline |
| Volume Number | 14 |
| Alternate Webpage(s) | https://ia800901.us.archive.org/21/items/pubmed-PMC4072408/PMC4072408-1471-2334-14-S4-O13.pdf |
| Alternate Webpage(s) | https://bmcinfectdis.biomedcentral.com/track/pdf/10.1186/1471-2334-14-S4-O13 |
| Alternate Webpage(s) | http://ftp.ncbi.nlm.nih.gov/pub/pmc/34/0d/1471-2334-14-S4-O13.PMC4072408.pdf |
| Alternate Webpage(s) | https://doi.org/10.1016/j.jcv.2014.07.009 |
| Journal | Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
