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Positron emission tomography in paediatric cardiology.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Quinlivan, Ros C. M. Robinson, Richard O. Maisey, Michael N. |
| Copyright Year | 1998 |
| Abstract | Types of PET study There are three types of cardiac PET study: regional blood flow (which can be measured at rest and during pharmacological induced stress), substrate metabolism, and chemical recognition (including receptors and enzymes). Currently, the main clinical application of PET is in the diagnosis of coronary artery disease, in terms of the diVerentiation between infarcted and “stunned” myocardial tissue, in which complete recovery of severely ischaemic and non-contracting myocardium is possible after reperfusion. 4 Other methods for diVerentiating recoverable myocardium from non-viable tissue, such as the presence of ECG Q waves, wall motion abnormalities on ultrasound, gated isotope scans, or fixed thallium201 perfusion defects, all seriously underestimate viable myocardium even with delayed imaging or reinjection techniques in the last. A number of tracers have been developed for clinical PET studies. These include oxygen-15, nitrogen-13, carbon-11, fluorine-18, and rubidium-82, all of which may be coupled to a number of physiologically active molecules. N-13 ammonia, Rb-82, and O-15 water can be used to assess myocardial blood flow. 6 7 Carbon-11 labelled fatty acids and F-18 deoxyglucose are commonly used metabolic tracers; C-11 acetate is used to assess oxidative metabolism and oxygen consumption. Because these tracers have very short half lives and relatively low radiation doses, it is possible to undertake sequential studies of perfusion and metabolism enabling accurate diVerentiation between stunned and infarcted tissue. 9 |
| Starting Page | 98 |
| Ending Page | 101 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://adc.bmj.com/content/archdischild/79/6/520.full.pdf |
| PubMed reference number | 10211000v1 |
| Volume Number | 79 |
| Issue Number | 6 |
| Journal | Archives of disease in childhood |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Ammonia Arteriopathic disease Artificial cardiac pacemaker Cardiology discipline Cell Respiration Congenital Abnormality Contract agreement Coronary Artery Disease Deoxyglucose Fatty Acids Glutamate-Ammonia Ligase Isotopes Metabolic Process, Cellular Myocardium Oxygen Consumption Pharmacology Positron-Emission Tomography Positrons Radionuclide Imaging Rubidium Tracer X-Ray Computed Tomography carbon-11 acetate fluorine-18 |
| Content Type | Text |
| Resource Type | Article |
