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In silico structural characterization of Mycobacterium tuberculosis H37Rv UDP-N-acetylmuramate dehydrogenase
| Content Provider | Semantic Scholar |
|---|---|
| Author | Babajan, Banaganapalli Anuradha, C. M. Chaitanya, M. Sai Gowsia, D. Chitta, Suresh Kumar |
| Copyright Year | 2009 |
| Abstract | Worldwide, tuberculosis (TB) remains the most frequent and important infectious disease causing morbidity and death. One-third of the world's population is infected with Mycobacterium tuberculosis (Mtb), the etiologic agent of TB. The World Health Organization estimates that about eight to ten million new TB cases occur annually worldwide and the incidence of TB is increasing. In this context, TB is in the top three, with malaria and HIV being the leading causes of death from a single infectious agent, and about two million deaths are attributable to TB annually. Here we present a 3D model of Mtb (UDP-N-acetylmuramate dehydrogenase) MurB using an in silico and secondary structure analysis, motifscan, validation, active site identification and substrate docking analysis reveals structural information for the development of new anti-tuberculosis drugs against Mtb. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://ijib.classicrus.com/IJIB/Arch/2009/1503.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
