Childhood adversity in schizophrenia: a systematic meta-analysis.

Content Provider	Semantic Scholar
Author	Matheson, Sandra L. Shepherd, Alana M. Pinchbeck, Robert Laurens, Kristin Robyn Carr, Vaughan J.
Copyright Year	2013
Abstract	BACKGROUND Childhood adversity is a putative risk factor for schizophrenia, although evidence supporting this suggestion is inconsistent and controversial. The aim of this review was to pool and quality assess the current evidence pertaining to childhood adversity in people with schizophrenia compared to other psychiatric disorders and to non-psychiatric controls. METHOD Included were case-control, cohort and cross-sectional studies. Medline, EMBASE and PsycINFO databases were searched. Study reporting was assessed using the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist and pooled evidence quality was assessed by the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. RESULTS Twenty-five studies met inclusion criteria. Moderate to high quality evidence suggests increased rates of childhood adversity in schizophrenia compared to controls [odds ratio (OR) 3.60, p < 0.00001]. Increased childhood adversity was also reported in schizophrenia compared to anxiety disorders (OR 2.54, p = 0.007), although the effect was not significant in the subgroup analysis of five studies assessing only sexual abuse. No differences in rates of childhood adversity were found between schizophrenia and affective psychosis, depression and personality disorders whereas decreased rates of childhood adversity were found in schizophrenia relative to dissociative disorders and post-traumatic stress disorder (OR 0.03, p < 0.0001). CONCLUSIONS This is the first meta-analysis to report a medium to large effect of childhood adversity in people with schizophrenia and to assess specificity for schizophrenia. Further research is required that incorporates longitudinal design and other potentially causal variables to assess additive and/or interactive effects.
Starting Page	11
Ending Page	11
Page Count	1
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.kcl.ac.uk/ioppn/depts/fans/sackler-group/Publications/20131/Childhoodadversityinschizophrenia-asystematicmata-analysis.pdf
PubMed reference number	22716913v1
Alternate Webpage(s)	https://doi.org/10.1017/S0033291712000785
DOI	10.1017/s0033291712000785
Journal	Psychological medicine
Volume Number	43
Issue Number	2
Language	English
Access Restriction	Open
Subject Keyword	Affective Disorders, Psychotic Anxiety Disorders Cross-Sectional Studies Depressive disorder Dissociative disorder Histopathologic Grade Mental disorders Odds Ratio Personality Disorders Physiological Sexual Disorders Pooled Sample Post-Traumatic Stress Disorder Psychotic Disorders Schizophrenia Stress Disorders, Traumatic
Content Type	Text
Resource Type	Article