NDLI: Reaction of sulphate radical anion (SO.4-) with hydroxy-and methyl-substituted pyrimidines: a pulse radiolysis study

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Reaction of sulphate radical anion (SO.4-) with hydroxy-and methyl-substituted pyrimidines: a pulse radiolysis study

Content Provider	Semantic Scholar
Author	Luke, T. L. Mohan, Hari Manoj, V. M. Manoj, P. Mittal, Jai Pal Aravindakumar, Charuvila T.
Copyright Year	2003
Abstract	Reactions of sulphate radical anion (SO·4-) with 4,6-dihydroxy-2-methyl pyrimidine (DHMP), 2,4-dimethyl-6-hydroxy pyrimidine (DMHP), 6-methyl uracil (MU) and 5,6-dimethyl uracil (DMU) have been studied by pulse radiolysis at pH 3 and at pH 10. The transient intermediate spectra were compared with those from the reaction of hydroxyl radical (·OH). It is proposed that SO·4- produces radical cations of these pyrimidines in the initial stage. These radical cations are short-lived except in the case of DMHP where a relatively longer lived radical cation is proposed to be formed. When there is a hydrogen atom attached to the N(1) or N(3) position, a deprotonation from these sites is highly favored. When there is no hydrogen attached to these sites, deprotonation from a substituted methyl group is favored. At acidic pH, deprotonation from nitrogen is observed for DHMP, MU and DMU. At basic pH, the radical cation reacts with OH- leading to the formation of OH adducts.
Starting Page	379
Ending Page	391
Page Count	13
File Format	PDF HTM / HTML
DOI	10.1163/156856703765694327
Alternate Webpage(s)	http://repository.ias.ac.in/25746/1/479.pdf
Alternate Webpage(s)	https://doi.org/10.1163/156856703765694327
Volume Number	29
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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