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Galectin-3 expression in papillary thyroid carcinoma: relation to histomorphologic growth pattern, lymph node metastasis, extrathyroid invasion, and tumor size.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Cvejić, Dubravka Savin, Svetlana B. Petrovic, Ivana M. Paunovic, Ivan Tatić, Svetislav B. Havelka, Marija J. |
| Copyright Year | 2005 |
| Abstract | BACKGROUND Galectin-3 has been recently recognized as a promising presurgical marker of thyroid malignancy. METHODS Galectin-3 expression was examined immunohistochemically in 202 specimens of papillary thyroid carcinoma (PTC) in relation to histomorphologic subtypes and clinicopathologic data. RESULTS.: The sensitivity of galectin-3 immunostaining versus conventional histology was 98% (100 of 102) for classical PTC, 85.2% (46 of 54) for follicular variant, and 50% (23 of 46) for follicular/solid variant of PTC. All cases (n = 36) involving lymph node metastases and 42 of 45 cases with extrathyroid invasion expressed galectin-3. However, among the galectin-3-positive cases (n = 169), 133 were without lymph node metastases, and 127 were without extrathyroid invasion. Galectin-3 expression was not related to the size of intrathyroid PTC. CONCLUSIONS Galectin-3 immunohistochemical expression itself is not an indicator of local metastatic spread or extrathyroid invasion of PTC, thus being irrelevant clinically from this aspect. Galectin-3 is an excellent marker for classical PTC but must be used with caution in diagnosing unconventional variants of PTC because of the possibility of false-negative results. |
| Starting Page | 897 |
| Ending Page | 900 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://sbccp.org.br/arquivos/HN_12-2005_galectin_3_expression_in_papillary.pdf |
| PubMed reference number | 16155918v1 |
| Volume Number | 27 |
| Issue Number | 12 |
| Journal | Head & neck |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Anatomic Node Galectin 3 Lymphadenopathy Neoplasms Papillary thyroid carcinoma Specimen Subtype (attribute) Thyroid Diseases cell growth pattern lymph node metastases lymph nodes |
| Content Type | Text |
| Resource Type | Article |
