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CCR 7 is required for the in vivo function of CD 4 + CD 25 + regulatory T cells
| Content Provider | Semantic Scholar |
|---|---|
| Author | Schneider, Martin A. Meingassner, Josef G. Lipp, Martin Moore, H. D. Rot, Antal |
| Copyright Year | 2007 |
| Abstract | JEM © The Rockefeller University Press $15.00 Vol. 204, No. 4, April 16, 2007 735–745 www.jem.org/cgi/doi/10.1084/jem.20061405 735 Effi cient adaptive immunity necessitates the encounter of exogenous antigens and rare antigen-specifi c immune cells in specialized microenvironments within the secondary lymphoid organs (SLOs; reference 1). The antigens are classically carried into the SLOs from the periphery by APCs. The cells of the adaptive arm of the immune system, particularly naive T cells, continue to recirculate via blood through the SLOs until they encounter their cognate antigen (2). The recognition of a cognate antigen by a T cell receptor in the context of MHC and with appropriate costimulation induces profound changes in T cell behavior, which signify the initiation of the adaptive immune response. According to the current paradigm, the two distinct migratory paths of APCs and T cells, which converge in the T cell zones of SLOs, are governed by the chemokine receptor CCR7 (3). CCR7 is highly expressed on mature DCs as well as on naive and central memory T cells (4), whereas its two chemokine ligands CCL19 and CCL21 are produced constitutively in the lymphoid organs and lymphatic vessels. The cardinal role of CCR7 in the homing and positioning of naive T cells and DCs in the SLOs and the ensuing eff ect on the immune response are illustrated by the profoundly disrupted cellular architecture of the SLOs in CCR7-defi cient (CCR7 KO) mice. Consequently CCR7 KO mice were shown to have a reduced ability to mount primary immune responses (5). However, recent studies indicate that adaptive immunity may develop through alternative pathways that do not involve CCR7. Peripheral antigens can diff use in soluble form into the SLOs, where after acquisition, processing, and presentation by the resident APCs, they can induce immune responses (6, 7). Also, alternative chemoattractant receptors may be substituting for CCR7 in inducing the homing of T cell and APC subsets into the SLOs (8–13). Therefore, we initially explored the contribution of CCR7 to the development of T cell immunity by setting up skin contact hypersensitivity CCR7 is required for the in vivo function of CD4+ CD25+ regulatory T cells |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://edoc.mdc-berlin.de/8791/1/8791oa.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
