NDLI: Temporal reproduction and its neuroanatomical correlates in adults with attention deficit hyperactivity disorder and their unaffected first-degree relatives.

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Temporal reproduction and its neuroanatomical correlates in adults with attention deficit hyperactivity disorder and their unaffected first-degree relatives.

Content Provider	Semantic Scholar
Author	Pironti, Valentino Antonio Morein-Zamir, Sharon Müller, Ulrich Bullmore, Edward T. Sahakian, Barbara J.
Copyright Year	2016
Abstract	BACKGROUND Little is known about time perception, its putative role as cognitive endophenotype, and its neuroanatomical underpinnings in adults with attention deficit hyperactivity disorder (ADHD). METHOD Twenty adults with ADHD, 20 unaffected first-degree relatives and 20 typically developing controls matched for age and gender undertook structural magnetic resonance imaging scans. Voxel-based morphometry with DARTEL was performed to obtain regional grey-matter volumes. Temporal processing was investigated as a putative cognitive endophenotype using a temporal reproduction paradigm. General linear modelling was employed to examine the relationship between temporal reproduction performances and grey-matter volumes. RESULTS ADHD participants were impaired in temporal reproduction and unaffected first-degree relatives performed in between their ADHD probands and typically developing controls. Increased grey-matter volume in the cerebellum was associated with poorer temporal reproduction performance. CONCLUSIONS Adults with ADHD are impaired in time reproduction. Performances of the unaffected first-degree relatives are in between ADHD relatives and controls, suggesting that time reproduction might be a cognitive endophenotype for adult ADHD. The cerebellum is involved in time reproduction and might play a role in driving time performances.
File Format	PDF HTM / HTML
DOI	10.1017/S003329171600101X
PubMed reference number	27345441
Journal	Medline
Volume Number	46
Issue Number	12
Alternate Webpage(s)	https://arro.anglia.ac.uk/700548/1/PSM-D-15-00108_R1%20(2)%20(1).pdf
Alternate Webpage(s)	https://doi.org/10.1017/S003329171600101X
Journal	Psychological medicine
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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