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Factors Associated with Immunological Discordance in HIV-Infected Patients Receiving Antiretroviral Therapy with Complete Viral Suppression in a Resource-Limited Setting.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Mingbunjerdsuk, Pornpimol Asdamongkol, Nakhon Sungkanuparph, Somnuek |
| Copyright Year | 2015 |
| Abstract | "Immunological discordance," i.e., immunological failure despite complete viral suppression in human immunodeficiency virus (HIV)-infected patients receiving antiretroviral therapy (ART), is associated with increased risk of AIDS or death. To evaluate risk factors for immunological discordance in a resource-limited setting in which patients usually present late with low CD4 cell counts, we conducted a case-control study among HIV-infected patients receiving ART and having undetectable HIV RNA. The study included patients with immunological discordance (cases), which was defined as CD4 cell count < 30% above baseline and absolute CD4 cell count < 200 cells/mm(3) at the first 12 months of undetectable HIV RNA (<50 copies/mL). Patients without immunological discordance were included as controls. Of 142 patients (44 cases; 98 controls), the mean age was 38.6 ± 9.4 years and 67.6% were men; 65.5% had history of opportunistic infections. In multivariate analysis, only baseline CD4 cell count < 100 cells/mm(3) (odd ratio [OR], 2.53; 95% confidence interval [CI], 1.04-6.14; P = 0.040) and history of lost to follow-up (OR, 11.04; 95% CI, 2.87-42.46; P < 0.001) were significantly associated with immunological discordance. Early initiation of ART and intervention to improve regular clinic visit compliance and adherence to ART are crucial to prevent immunological discordance among HIV-infected patients. |
| Starting Page | 472 |
| Ending Page | 483 |
| Page Count | 12 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.jstage.jst.go.jp/article/yoken/68/4/68_JJID.2014.062/_pdf/-char/en |
| PubMed reference number | 25720640v1 |
| Alternate Webpage(s) | https://doi.org/10.7883/yoken.JJID.2014.062 |
| DOI | 10.7883/yoken.jjid.2014.062 |
| Journal | Japanese journal of infectious diseases |
| Volume Number | 68 |
| Issue Number | 4 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acquired Immunodeficiency Syndrome Antiretroviral therapy BaseLine dental cement Cell Count Cessation of life Confidence Intervals Copy (object) HIV Infections Immunologic Deficiency Syndromes Odds Ratio Opportunistic Infections Patients Virus Diseases |
| Content Type | Text |
| Resource Type | Article |
