NDLI: Prestretched airway smooth muscle response to length oscillation

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Prestretched airway smooth muscle response to length oscillation

Content Provider	Semantic Scholar
Author	Jumaily, Ahmed M. Al‐ Roos, Kevin M. Bessaguet, Sandy Avila, Miguel Jo
Copyright Year	2017
Abstract	Airway smooth muscle (ASM) hyperconstriction is the cause of many respiratory diseases including asthma. In vitro testing has demonstrated that the active forces of ASM are reduced by length oscillation (LO) mimicking tidal breathing. In a previous study, we demonstrated that this force reduction can be further enhanced when superimposing oscillations (with certain frequencies and amplitudes) on this LO In contrast, it has been reported that pressurizing the lung may help in relieving asthmatic airway constrictions. Ultimately, this pressurizing stretches the ASM and may disturb the acto-myosin cross-bridges in a manner similar to LO; however, it is of a static rather than dynamic nature. This research investigates the effect of combining both prestretch- and LO-applications on contracted porcine ASM Isolated porcine ASM relaxation was tested with a 0.56%, 2%, or 4% stretch of its reference length (Lref) in addition to LO These oscillations are composed of a main wave mimicking the normal breathing (frequency of 0.33 Hz and amplitude of 4% Lref) and superimposed oscillations (frequencies of 20, 30, 40, 60 and 80 Hz and amplitude of 1% Lref). The oscillations were maintained for 10 min. The results demonstrate that a prestretch of 0.56% and 2% Lref does enhance the contracted ASM relaxation at certain superimposed length oscillations frequencies while of 4% Lref does not.
Starting Page	L286
Ending Page	L294
Page Count	1
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://physreports.physiology.org/content/physreports/5/2/e13076.full.pdf
PubMed reference number	28126731
Alternate Webpage(s)	https://doi.org/10.14814/phy2.13076
DOI	10.14814/phy2.13076
Journal	Physiological reports
Volume Number	5
Language	English
Access Restriction	Open
Subject Keyword	Asthma Constriction procedure Eighty Hertz (Hz) High-Frequency Oscillation Ventilation Myalgia Porcine species Respiration Disorders Smooth muscle (tissue) Structure of parenchyma of lung breathing pain
Content Type	Text
Resource Type	Article

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