NDLI: Global antifungal profile optimization of chlorophenyl derivatives against Botrytis cinerea and Colletotrichum gloeosporioides.

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Global antifungal profile optimization of chlorophenyl derivatives against Botrytis cinerea and Colletotrichum gloeosporioides.

Content Provider	Semantic Scholar
Author	Saíz-Urra, Liane Pérez, Antonio J. Bustillo Cruz-Monteagudo, Maykel Pinedo-Rivilla, Cristina Aleu, Josefina Hernández-Galán, Rosario Collado, Isidro G.
Copyright Year	2009
Abstract	Twenty-two aromatic derivatives bearing a chlorine atom and a different chain in the para or meta position were prepared and evaluated for their in vitro antifungal activity against the phytopathogenic fungi Botrytis cinerea and Colletotrichum gloeosporioides. The results showed that maximum inhibition of the growth of these fungi was exhibited for enantiomers S and R of 1-(4'-chlorophenyl)-2-phenylethanol (3 and 4). Furthermore, their antifungal activity showed a clear structure-activity relationship (SAR) trend confirming the importance of the benzyl hydroxyl group in the inhibitory mechanism of the compounds studied. Additionally, a multiobjective optimization study of the global antifungal profile of chlorophenyl derivatives was conducted in order to establish a rational strategy for the filtering of new fungicide candidates from combinatorial libraries. The MOOP-DESIRE methodology was used for this purpose providing reliable ranking models that can be used later.
File Format	PDF HTM / HTML
DOI	10.1021/jf900375x
PubMed reference number	19489624
Journal	Medline
Volume Number	57
Issue Number	11
Alternate Webpage(s)	http://rodin.uca.es/xmlui/bitstream/handle/10498/17358/Articulo%20bioensayos.pdf;jsessionid=F29B0C574D125E9459EBC47C41DDE7C7?sequence=1
Alternate Webpage(s)	https://doi.org/10.1021/jf900375x
Journal	Journal of agricultural and food chemistry
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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