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Peri-Procedural Platelet Reactivity in Percutaneous Coronary Intervention.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Alexopoulos, Dimitrios Xenogiannis, Iosif Vlachakis, Panagiotis Tantry, Udaya S. Gurbel, Paul A. |
| Copyright Year | 2018 |
| Abstract | Platelet activation and aggregation play a pivotal role in thrombotic complications occurring during percutaneous coronary intervention (PCI), and peri-PCI anti-platelet therapy represents a standard of care. High platelet reactivity prior to PCI has been correlated with an increased incidence of peri-procedural myonecrosis. Pre-PCI platelet reactivity predicts post-PCI platelet reactivity and has a prognostic impact on subsequent ischaemic and bleeding events, so as the platelet inhibition measured post-PCI. Many anti-platelet treatment strategies, including aspirin, glycoprotein IIb/IIIa inhibitors, P2Y12 receptor blockers and vorapaxar, are being used in the routine clinical practice to modify platelet reactivity at each stage, e.g. pre-, during and post-PCI. Anti-platelet strategies with a 'stronger and faster' pharmacodynamic effect than clopidogrel have been mostly adopted in patients with acute coronary syndromes. However, several issues regarding the anti-platelet treatment such as benefits/risks of anti-platelet therapy pre-treatment and duration, and definite association between speed and potency of various anti-platelet agents and clinical outcomes remain controversial. We believe that a better understanding of peri-PCI platelet reactivity and its relations to outcomes may lead to the development of more effective and safe treatment strategies. |
| Starting Page | 1131 |
| Ending Page | 1140 |
| Page Count | 10 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-0038-1649484.pdf |
| PubMed reference number | 29864784v1 |
| Alternate Webpage(s) | https://doi.org/10.1055/s-0038-1649484 |
| DOI | 10.1055/s-0038-1649484 |
| Journal | Thrombosis and haemostasis |
| Volume Number | 118 |
| Issue Number | 7 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acute Coronary Syndrome Aspirin Blood Platelet Disorders Blood Platelets Dosage Forms Entity Name Part Qualifier - adopted Hemorrhage Myopathy Oral cavity Patients Percutaneous Coronary Intervention Platelet Count measurement Platelet Glycoprotein GPIIb-IIIa Complex Purpura, Thrombotic Thrombocytopenic benefit clopidogrel funding grant protein C inhibitor-acrosin complex vorapaxar |
| Content Type | Text |
| Resource Type | Article |
