Failure of exogenous insulin to inhibit C-peptide release from the perfused rat pancreas.

Content Provider	Semantic Scholar
Author	Tanaka, Ryota Shima, Keisetsu Sawazaki, N. Matsuyama, Taizo Kumahara, Yuichi Yanaihara, Noboru
Copyright Year	1980
Abstract	In order to ascertain whether insulin secretion is inhibited by insulin per se, the effect of exogenous rat insulin on basal and stimulated rat C-peptide reactivity (CPR) release was studied in the isolated perfused rat pancreas. The pancreas was perfused with a medium containing 20 or 200 ng/ml of rat insulin for a 20 min equilibration period and successively for a 25 to 30 min test period during which time glucose (300 mg/100 ml), tolbutamide (500 micrograms/ml), glucagon (500 ng/ml) or arginine (10 mM) was added as a secretagogue. The concentration of glucose in the basal medium was 60 mg/100 ml. Exogenous insulin did not significantly suppress the basal CPR secretion, nor did it cause a suppression of the peak value or incremental area of CPR while the pancreas was stimulated, but it rather augmented them. No inhibitory effect of exogenous insulin on the basal or stimulated CPR release was noticed in the present study.
Starting Page	179
Ending Page	212
Page Count	34
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.jstage.jst.go.jp/article/endocrj1954/27/3/27_3_343/_pdf/-char/en
PubMed reference number	7002534v1
Volume Number	27
Issue Number	3
Journal	Endocrinologia japonica
Language	English
Access Restriction	Open
Subject Keyword	Arginine Cardiopulmonary Resuscitation Glucose Increment Microgram per Liter Pancreas extract Tolbutamide insulin secretion
Content Type	Text
Resource Type	Article