Loading...
Please wait, while we are loading the content...
Similar Documents
The non-receptor tyrosine kinase TNK2/ACK1 is a novel therapeutic target in triple negative breast cancer
| Content Provider | Semantic Scholar |
|---|---|
| Author | Wu, Xinyan Saddiq, Muhammad Zahari Renuse, Santosh Kelkar, Dhanashree S. Barbhuiya, Mustafa Ahmed Rojas, Pamela A. Leal Stearns, Vered Gabrielson, Edward W. Malla, Pavani Sukumar, Selvakumar Mahajan, Nupam P. Pandey, Akhilesh |
| Copyright Year | 2017 |
| Abstract | Breast cancer is the most prevalent cancer in women worldwide. About 15-20% of all breast cancers do not express estrogen receptor, progesterone receptor or HER2 receptor and hence are collectively classified as triple negative breast cancer (TNBC). These tumors are often relatively aggressive when compared to other types of breast cancer, and this issue is compounded by the lack of effective targeted therapy. In our previous phosphoproteomic profiling effort, we identified the non-receptor tyrosine kinase TNK2 as activated in a majority of aggressive TNBC cell lines. In the current study, we show that high expression of TNK2 in breast cancer cell lines correlates with high proliferation, invasion and colony forming ability. We demonstrate that knockdown of TNK2 expression can substantially suppress the invasiveness and proliferation advantage of TNBC cells in vitro and tumor formation in xenograft mouse models. Moreover, inhibition of TNK2 with small molecule inhibitor (R)-9bMS significantly compromised TNBC proliferation.Finally, we find that high levels of TNK2 expression in high-grade basal-like breast cancers correlates significantly with poorer patient outcome. Taken together, our study suggests that TNK2 is a novel potential therapeutic target for the treatment of TNBC. |
| Starting Page | 2971 |
| Ending Page | 2983 |
| Page Count | 13 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&op=download&page=article&path%5B%5D=13579&path%5B%5D=43131 |
| PubMed reference number | 27902967 |
| Alternate Webpage(s) | https://doi.org/10.18632/oncotarget.13579 |
| DOI | 10.18632/oncotarget.13579 |
| Journal | Oncotarget |
| Volume Number | 8 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Classification Cultured Cell Line Estrogens Mammary Neoplasms Protein Tyrosine Kinase Receptor Protein-Tyrosine Kinases Receptors, Progesterone Small Molecule TNK2 gene Triple Negative Breast Neoplasms Xenograft type of graft estrogen receptor alpha, human |
| Content Type | Text |
| Resource Type | Article |
