NDLI: Delayed rectifier and Ca2+-dependent K+ currents in human esophagus: roles in regulating muscle contraction.

Please wait, while we are loading the content...

Delayed rectifier and Ca2+-dependent K+ currents in human esophagus: roles in regulating muscle contraction.

Content Provider	Semantic Scholar
Author	Wade, Gregory R. Laurier, Lisanne G. Preiksaitis, Harold G. Sims, S. M.
Copyright Year	1999
Abstract	We have examined K+ channels and their function in human esophageal smooth muscle using perforated patch recording, RT-PCR to identify channel mRNA, and muscle contraction to study the effects of channel blockers. Depolarization revealed at least two types of currents: a 4-aminopyridine (4-AP)-sensitive transient delayed rectifier K+(KV) and a Ca2+-dependent K+(KCa) current. KCa current was active at positive potentials and was blocked by tetraethylammonium (TEA), iberiotoxin, and charybdotoxin but was insensitive to 4-AP. The mRNA encoding the gene products of Kv1.2 and Kv1.5 was identified in muscle and dissociated cells, consistent with these channel types contributing to KV current. 4-AP increased resting tension of muscle strips, suggesting a role for KV in setting the membrane potential. TEA, but not 4-AP, augmented the amplitude and duration of electrically evoked contraction, effects that were abolished by nifedipine. Here we provide the first description of macroscopic K+ currents in human esophagus. KV channels participate in regulation of resting tension, whereas the KCa channel limits depolarization and contraction during excitation.
Starting Page	G885
Ending Page	G895
Page Count	1
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://ajpgi.physiology.org/content/ajpgi/277/4/G885.full.pdf
PubMed reference number	29591403v1
Alternate Webpage(s)	https://doi.org/10.1152/ajpgi.1999.277.4.G885
DOI	10.1152/ajpgi.1999.277.4.g885
Journal	American journal of physiology. Gastrointestinal and liver physiology
Volume Number	277
Issue Number	4
Language	English
Access Restriction	Open
Subject Keyword	CSN3 gene Calcium ion Charybdotoxin Contribution Electricity Esophagus Excitation Membrane Potentials Muscle Contraction Myalgia Nifedipine Rectifier Device Component Rest Smooth muscle (tissue) Tension Tetraethylammonium dalfampridine iberiotoxin strip medical device
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in