NDLI: Food deprivation induces monocarboxylate transporter 2 expression in the brainstem of female rat.

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Food deprivation induces monocarboxylate transporter 2 expression in the brainstem of female rat.

Content Provider	Semantic Scholar
Author	Matsuyama, Shuichi Ohkura, Satoshi Iwata, Kinuyo Uenoyama, Yoshihisa Tsukamura, Hiroko Kei-Ichiro Kimura, Koji
Copyright Year	2009
Abstract	Ketone bodies are considered to act as a signal to suppress gonadotropin release during negative energy balance. The present study examined the effect of 48-h fasting on the mRNA expressions of monocarboxylate transporter 1 (MCT1) and MCT2, which are involved in ketone body transport, in several brain regions. Quantitative real-time RT-PCR analysis showed that the MCT2 mRNA levels were significantly increased by 48-h fasting in the area postrema-solitary tract nucleus (AP-NTS) region but not the arcuate nucleus-ventromedial hypothalamic nucleus (ARC-VMH) and central gray-supragenual nucleus around the 4th ventricle (CG-SGe) regions. Fasting did not significantly affect MCT1 mRNA expression in any of the brain areas examined. Luteinizing hormone (LH) pulse frequency significantly decreased and plasma concentrations of beta-hydroxybutyric acid, a ketone body, significantly increased after 48-h fasting. The present results suggest that increased uptake of ketone bodies via MCT2 in the AP-NTS region is likely involved in the mechanism of fasting-induced suppression of LH secretion in rats.
Starting Page	3 pp.
Ending Page	3 pp.
Page Count	1
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.jstage.jst.go.jp/article/jrd/55/3/55_20214/_pdf
PubMed reference number	19262019v1
Volume Number	55
Issue Number	3
Journal	The Journal of reproduction and development
Language	English
Access Restriction	Open
Subject Keyword	3-Hydroxybutyric Acid Brain Stem Cell Nucleus Corpora paraaortica Fourth ventricle structure Gonadorelin Gonadotropins Ketone Bodies Ketones Luteinizing Hormone Nucleus solitarius Structure of area postrema Structure of nucleus infundibularis hypothalami Structure of ventromedial hypothalamic nucleus Thioctic Acid dopamine transporter energy balance
Content Type	Text
Resource Type	Article

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