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Antisense effect of pyrrolidine-based oxy-peptide nucleic acids in Escherichia coli.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kitamatsu, Mizuki Kurami, Shunsuke Ohtsuki, Takashi Sisido, Masahiko |
| Copyright Year | 2011 |
| Abstract | To investigate the antisense effect of a pyrrolidine-based oxy-peptide nucleic acid (POPNA), we carried out the LacZ reporter assay using a 12-mer trans-l-POPNA conjugated with a cell-penetrating peptide (antisense reagent). The antisense effect of the conjugated POPNA (inhibition of LacZ activity) was comparable to that shown by a Nielsen-type peptide nucleic acid. Furthermore, the conjugated POPNA could switch the LacZ activity over a wide range of ambient temperatures. |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.bmcl.2010.11.034 |
| PubMed reference number | 21112781 |
| Journal | Medline |
| Volume Number | 21 |
| Issue Number | 1 |
| Alternate Webpage(s) | http://ousar.lib.okayama-u.ac.jp/files/public/4/46919/20160528082104221115/BMCL_21_1_225-227.pdf |
| Alternate Webpage(s) | https://doi.org/10.1016/j.bmcl.2010.11.034 |
| Journal | Bioorganic & medicinal chemistry letters |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
