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Evaluation of deformable image registration algorithm for determination of accumulated dose for brachytherapy of cervical cancer patients
| Content Provider | Semantic Scholar |
|---|---|
| Author | Mohammadi, Reza Mahdavi, Seied Rabie Jaberi, Ramin Siavashpour, Zahra Janani, Leila Meigooni, Ali Soleimani Reiazi, Reza |
| Copyright Year | 2019 |
| Abstract | Purpose This study was designed to assess the dose accumulation (DA) of bladder and rectum between brachytherapy fractions using hybrid-based deformable image registration (DIR) and compare it with the simple summation (SS) approach of GEC-ESTRO in cervical cancer patients. Material and methods Patients (n = 137) with cervical cancer treated with 3D conformal radiotherapy and three fractions of high-dose-rate brachytherapy were selected. CT images were acquired to delineate organs at risk and targets according to GEC-ESTRO recommendations. In order to determine the DA for the bladder and rectum, hybrid-based DIR was done for three different fractions of brachytherapy and the results were compared with the standard GEC-ESTRO method. Also, we performed a phantom study to calculate the uncertainty of the hybrid-based DIR algorithm for contour matching and dose mapping. Results The mean ± standard deviation (SD) of the Dice similarity coefficient (DICE), Jaccard, Hausdorff distance (HD) and mean distance to agreement (MDA) in the DIR process were 0.94 ±0.02, 0.89 ±0.03, 8.44 ±3.56 and 0.72 ±0.22 for bladder and 0.89 ±0.05, 0.80 ±0.07, 15.46 ±10.14 and 1.19 ±0.59 for rectum, respectively. The median (Q1, Q3; maximum) GyEQD2 differences of total D2cc between DIR-based and SS methods for the bladder and rectum were reduced by -1.53 (-0.86, -2.98; -9.17) and -1.38 (-0.80, -2.14; -7.11), respectively. The mean ± SD of DICE, Jaccard, HD, and MDA for contour matching were 0.98 ±0.008, 0.97 ±0.01, 2.00 ±0.70 and 0.20 ±0.04, respectively for large deformation. Maximum uncertainty of dose mapping was about 3.58%. Conclusions The hybrid-based DIR algorithm demonstrated low registration uncertainty for both contour matching and dose mapping. The DA difference between DIR-based and SS approaches was statistically significant for both bladder and rectum and hybrid-based DIR showed potential to assess DA between brachytherapy fractions. |
| Starting Page | 469 |
| Ending Page | 478 |
| Page Count | 10 |
| File Format | PDF HTM / HTML |
| DOI | 10.5114/jcb.2019.88762 |
| PubMed reference number | 31749857 |
| Journal | Medline |
| Volume Number | 11 |
| Alternate Webpage(s) | https://www.termedia.pl/Journal/-54/pdf-38045-10?filename=Evaluation+of+deformable.pdf |
| Alternate Webpage(s) | https://doi.org/10.5114/jcb.2019.88762 |
| Journal | Journal of contemporary brachytherapy |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
