NDLI: Reactive oxygen metabolites relax the lamb ductus arteriosus by stimulating prostaglandin production.

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Reactive oxygen metabolites relax the lamb ductus arteriosus by stimulating prostaglandin production.

Content Provider	Semantic Scholar
Author	Clyman, Ronald I. Saugstad, Ola Dibrik Mauray, Françoise
Copyright Year	1989
Abstract	To determine whether oxygen metabolites can cause ductus relaxation, we used rings of fetal ductus obtained from 36 near-term lambs and measured the effects of the oxygen metabolites generated by the combination of hypoxanthine and xanthine oxidase. The oxygen metabolites produced by hypoxanthine plus xanthine oxidase caused relaxation of the ductus that was inhibited by catalase (hydrogen peroxide scavenger) but not by superoxide dismutase (superoxide anion scavenger). In addition, hypoxanthine plus xanthine oxidase produced a 14-fold increase in prostaglandin (PG) E2 production with only twofold increase in 6-keto-PGF1 alpha (the stable metabolite of PGI2). PGE2 is the most potent relaxant of the ductus arteriosus. The presence of either catalase or indomethacin blocked both the increase in prostaglandin production and the relaxation. We conclude that reactive oxygen metabolites relax the ductus arteriosus and oppose the normal constriction that occurs after birth. However, the vasoactive effects of reactive oxygen metabolites in the ductus appear to be mediated exclusively through the generation of PGE2.
Starting Page	1
Ending Page	8
Page Count	8
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://circres.ahajournals.org/content/circresaha/64/1/1.full.pdf
Alternate Webpage(s)	http://circres.ahajournals.org/content/circresaha/64/1/1.full.pdf?download=true
PubMed reference number	2909293v1
Volume Number	64
Issue Number	1
Journal	Circulation research
Language	English
Access Restriction	Open
Subject Keyword	Anions CATALASE Dinoprostone Domestic Sheep Epoprostenol Estradiol Gas Scavengers Hydrogen Peroxide Hypoxanthine Indomethacin Oxygen Peroxides Prostaglandin Production Prostaglandin-Endoperoxide Synthase Prostaglandins Stimulation (motivation) Structure of ductus arteriosus Superoxide Dismutase Superoxides Xanthine Oxidase type I interferon receptor
Content Type	Text
Resource Type	Article

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