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The synthesis of polyhydroxy sterone 2β,3α,5-trihydroxy-5α-androst-6-one and its neuroprotection
| Content Provider | Semantic Scholar |
|---|---|
| Author | Xie, Minyu Li, Xinhua Yuan, Li Chen, Yiyu Zhang, Xiaolei Lu, Bingzheng Shi, Haitao Zhang, Jingxia |
| Copyright Year | 2017 |
| Abstract | Neuroactive steroids exhibit better neuroprotective properties in vitro and in vivo, and will be a potential neuroprotective effect. In this study, polyhydroxy sterone 2β,3α,5-trihydroxy-5α- androst-6-one (YC-10) was designed and synthesized from androst-5-en-3-ol by 6 steps reactions. Its absolute structure was characterized by X-SRD and its structure was characterized by NMR, IR, and MS. Its neuroprotective action was determined by MTT assay with two models of neurotoxicity. The maximum protective effect was at a concentration of 40μM for neurotoxicity induced by glutamate, and showing better cell viability in a dose-dependent manner; Moreover it cloud significantly protect the cerebellar granule neurons against neuronal death mediated by low K + , its effective protective concentration was 50μM. |
| File Format | PDF HTM / HTML |
| DOI | 10.14800/ttnd.1559 |
| Volume Number | 4 |
| Alternate Webpage(s) | http://www.smartscitech.com/index.php/TTND/article/download/1559/pdf |
| Alternate Webpage(s) | https://doi.org/10.14800/ttnd.1559 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |