NDLI: Precursor frequency analysis of lymphokine-secreting alloreactive T lymphocytes. Dissociation of subsets producing interleukin 2, macrophage-activating factor, and granulocyte-macrophage colony- stimulating factor on the basis of Lyt-2 phenotype

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Precursor frequency analysis of lymphokine-secreting alloreactive T lymphocytes. Dissociation of subsets producing interleukin 2, macrophage-activating factor, and granulocyte-macrophage colony- stimulating factor on the basis of Lyt-2 phenotype

Content Provider	Semantic Scholar
Author	Kelso, Anne Macdonald, H. Robson
Copyright Year	1982
Abstract	The frequencies of precursors of C57BL/6 T lymphocytes that respond to DBA/2 alloantigens by secreting the lymphokines interleukin 2 (IL-2), macrophage-activating factor (MAF), and granulocyte-macrophage colony-stimulating factor (GM-CSF) have been directly compared with cytolytic T lymphocyte precursor (CTL-P) frequencies in limiting dilution microcultures established from spleen cells positively or negatively selected on the basis of Lyt-2 phenotype. A clear dichotomy was observed between CTL-P, which were contained in the Lyt-2+ fraction, and precursors of IL-2-secreting cells, which were detected almost exclusively in the Lyt-2- population. In contrast, precursors of cells secreting MAF and GM-CSF were found in both populations: almost all responding cells from the Lyt-2- fraction produced both these factors, whereas the precursor frequency of MAF-secreting and GM-CSF-secreting cells was three- to fourfold lower in the Lyt-2+ population. These frequency data were consistent with quantitative differences observed in the average production of these lymphokines by Lyt-2+ and Lyt-2- populations.
Starting Page	1366
Ending Page	1379
Page Count	14
File Format	PDF HTM / HTML
PubMed reference number	6752327v1
Volume Number	156
Journal	The Journal of experimental medicine
Alternate Webpage(s)	https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3c/af/je15651366.PMC2186845.pdf
Language	English
Access Restriction	Open
Subject Keyword	1-palmitoyl-2-oleoyl-phosphatidyl-uridine Anemia, Diamond-Blackfan C57BL/6 Mouse Cell secretion Colony-Stimulating Factors Contain (action) Cytotoxic T-Lymphocytes Gentamicins Granulocyte-Macrophage Colony-Stimulating Factor Helper-Inducer T-Lymphocyte Interleukin-2 Interleukins Lymphocyte Count measurement Mice, Inbred C57BL Mice, Inbred DBA Recombinant Lymphokine Spleen Tissue Stimulation (motivation) granulocyte
Content Type	Text
Resource Type	Article

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