NDLI: Da Leptina Em Adipócitos De Bovinos De Corte

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Da Leptina Em Adipócitos De Bovinos De Corte

Content Provider	Semantic Scholar
Author	Passos, Daniel Thompsen
Copyright Year	2006
Abstract	1 2 Polymorphisms at leptin gene may affect gene expression and, in beef 3 cattle, the alleles IDVGA51181 and LEPSau3A12 have been described as 4 increasing calving interval (CI), and BMS1074151 and BM1500135 as 5 affecting daily weight gain. In order to verify the effect of these alleles on LEP 6 gene transcription, this work analyzed LEP mRNA levels on cattle 7 subcutaneous and omental adipose tissues through Real-Time RT-PCR. A 8 sample of 137 females of a Brangus-Ibage herd was previously analyzed in 9 relation to these polymorphisms distribution; then animals presenting only 10 one of the IDVGA51181 (n=6), LEPSau3A12 (n=4), BMS1074151 (n=13), 11 BM1500135 (n=6) alleles and a control group composed by animals without 12 any of these alleles (n=4) were submitted to surgery to obtain omental and 13 subcutaneous adipose tissues. Leptin mRNA expression was quantified by 14 TaqMan Real-Time RT-PCR, using 18S rRNA as internal control. Leptin 15 expression was adjusted for the effect of body score condition, through 16 regression analysis. Omental fat had LEP gene expression 33% lower than 17 the subcutaneous tissue. Carrier animals of IDVGA181 and BMS1074151 18 alleles showed subcutaneous fat mRNA leptin levels higher than the controls. 19 As leptin controls food intake, animals with higher LEP gene expression will 20 probably have less daily weight gain than the other in similar forage offer and 21 nutritional condition. Leptin coordinate also reproductive function, and in 22 cattle, antagonizes insulin's stimulatory effect on steroidogenesis; therefore, 23 animals with higher LEP gene expression will probably have longer CI. 24
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://lume.ufrgs.br/bitstream/handle/10183/7490/000546172.pdf;sequence=1
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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