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Effect of a fermented milk containing Bifidobacterium animalis DN-173 010 on the health-related quality of life and symptoms in irritable bowel syndrome in adults in primary care: a multicentre, randomized, double-blind, controlled trial.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Guyonnet, Denis Chassany, Olivier Ducrotte, Phillipe Picard, Céline Mouret, Michel Mercier, C. Matuchansky, C. |
| Copyright Year | 2007 |
| Abstract | BACKGROUND Health-related quality of life (HRQoL) has been rarely evaluated as a primary endpoint in the assessment of the effect of probiotics on the irritable bowel syndrome (IBS). AIM To study the effects of fermented milk containing Bifidobacterium animalis DN-173 010 and yoghurt strains on the IBS in a multicentre, double-blind, controlled trial. METHODS A total of 274 primary care adults with constipation-predominant IBS (Rome II) were randomized to consume for 6 weeks either the test fermented milk or a heat-treated yoghurt (control). HRQoL and digestive symptoms were assessed after 3 and 6 weeks on an intention-to-treat population of 267 subjects. RESULTS The HRQoL discomfort score, the primary endpoint, improved (P < 0.001) in both groups at weeks 3 and 6. The responder rate for the HRQoL discomfort score was higher (65.2 vs. 47.7%, P < 0.005), as was the decrease in bloating score [0.56 +/- (s.d.)1.01 vs. 0.31 +/- 0.87, P = 0.03], at week 3 in the test vs. the control group. In those subjects with <3 stools/week, stool frequency increased (P < 0.001) over 6 weeks in the test vs. control group. CONCLUSIONS This study suggests a beneficial effect of a probiotic food on discomfort HRQoL score and bloating in constipation-predominant IBS, and on stool frequency in subjects with <3 stools/week. |
| File Format | PDF HTM / HTML |
| DOI | 10.1111/j.1365-2036.2007.03362.x |
| PubMed reference number | 17635382 |
| Journal | Medline |
| Volume Number | 26 |
| Issue Number | 3 |
| Alternate Webpage(s) | http://hmphanmi.com.cn/hmp/upload/event/study_6/9.pdf |
| Alternate Webpage(s) | https://doi.org/10.1111/j.1365-2036.2007.03362.x |
| Journal | Alimentary pharmacology & therapeutics |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
