NDLI: Direct analysis in real time mass spectrometry (DART-MS) of "bath salt" cathinone drug mixtures.

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Direct analysis in real time mass spectrometry (DART-MS) of "bath salt" cathinone drug mixtures.

Content Provider	Semantic Scholar
Author	Lesiak, Ashton D. Musah, Rabi Ann Cody, Robert B. Domin, Marek Dane, A. John Shepard, Jason R. E.
Copyright Year	2013
Abstract	Rapid and versatile direct analysis in real time mass spectrometry (DART-MS) methods were developed for detection and characterization of synthetic cathinone designer drugs, also known as "bath salts". The speed and efficiency associated with DART-MS testing of such highly unpredictable samples demonstrate the technique as an attractive alternative to conventional GC-MS and LC-MS methods. A series of isobaric and closely related synthetic cathinones, alone and in mixtures, were differentiated using high mass accuracy and in-source collision induced dissociation (CID). Crime laboratories have observed a dramatic rise in the use of these substances, which has caused sample testing backlogs, particularly since the myriad of structurally related compounds are challenging to efficiently differentiate. This challenge is compounded by the perpetual emergence of new structural variants as soon as older generation derivatives become scheduled. Because of the numerous chemical substances that fall into these categories, along with the varying composition and complexity of mixtures of these drugs, DART-MS CID has the potential to dramatically streamline sample analysis, minimize the number of sample preparation steps, and enable rapid characterization of emerging structural analogs.
File Format	PDF HTM / HTML
DOI	10.1039/c3an00360d
PubMed reference number	23636110
Journal	Medline
Volume Number	138
Issue Number	12
Alternate Webpage(s)	https://static1.squarespace.com/static/5303c335e4b067ebfee167a4/t/53bc3814e4b0b59a66e51d5c/1404844052964/Direct+analysis+in+real+time+mass+spectrometry_DART-MS+of+bath+salt+cathinone+drug+mixtures.pdf
Alternate Webpage(s)	https://www.safetylit.org/citations/ild_request_form.php?article_id=citjournalarticle_397053_1
Alternate Webpage(s)	https://doi.org/10.1039/c3an00360d
Journal	The Analyst
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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