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Normal insulin sensitivity and IMCL content in overweight humans are associated with higher fasting lipid oxidation.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Perseghin, Gianluca Scifo, Paola Danna, Massimo Battezzati, Alberto Benedini, Stefano Meneghini, Elena Maschio, Alessandro Del Luzi, Livio |
| Copyright Year | 2002 |
| Abstract | Intramyocellular lipid (IMCL) storage is considered a local marker of whole body insulin resistance; because increments of body weight are supposed to impair insulin sensitivity, this study was designed to assess IMCL content, lipid oxidation, and insulin action in individuals with a moderate increment of body fat mass and no family history of diabetes. We studied 14 young, nonobese women with body fat <30% (n = 7) or >30% (n = 7) and 14 young, nonobese men with body fat <25% (n = 7) or >25% (n = 7) by means of the euglycemic-insulin clamp to assess whole body glucose metabolism, with indirect calorimetry to assess lipid oxidation, by localized (1)H NMR spectroscopy of the calf muscles to assess IMCL content, and with dual-energy X-ray absorptiometry to assess body composition. Subjects with higher body fat had normal insulin-stimulated glucose disposal (P = 0.80), IMCL content in both soleus (P = 0.22) and tibialis anterior (P = 0.75) muscles, and plasma free fatty acid levels (P = 0.075) compared with leaner subjects in association with increased lipid oxidation (P < 0.05), resting energy expenditure (P = 0.046), resting oxygen consumption (P = 0.049), and plasma leptin levels (P < 0.01) in the postabsorptive condition. In conclusion, in overweight subjects, preservation of insulin sensitivity was combined with increased lipid oxidation and maintenance of normal IMCL content, suggesting that abnormalities of these factors may mutually determine the development of insulin resistance associated with weight gain. |
| Starting Page | 1159 |
| Ending Page | 1162 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://ajpendo.physiology.org/content/ajpendo/283/3/E556.full.pdf |
| Alternate Webpage(s) | http://ajpendo.physiology.org/content/ajpendo/283/3/e556.full.pdf |
| PubMed reference number | 12169449v1 |
| Volume Number | 283 |
| Issue Number | 3 |
| Journal | American journal of physiology. Endocrinology and metabolism |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adipose tissue Biologic Preservation Body Composition Calorimetry Calorimetry, Indirect Congenital Abnormality Diabetes Mellitus Disposal Dual Dual-Energy X-Ray Absorptiometry FAT1 gene Family History Domain Heparin, Low-Molecular-Weight Increment Insulin Resistance Lipid Metabolism Disorders Near Edge X-Ray Absorption Fine Structure Spectroscopy Nonesterified Fatty Acids Overweight Oxygen Consumption Plain x-ray Platelet Glycoprotein 4, human Rest Soleus muscle structure Structure of calf of leg Tibialis anterior muscle structure glucose metabolism insulin, isophane leptin lipid oxidation |
| Content Type | Text |
| Resource Type | Article |
