New evidence of TERT rs2736098 polymorphism and cancer risk: an updated meta-analysis.

Content Provider	Semantic Scholar
Author	Li, Tong Xian, Yun Tian, Tian Zhuang, Xun Chu, Minjie
Copyright Year	2016
Abstract	PURPOSE Previous meta-analyses didn't suggest any significant association between TERT rs2736098 polymorphism and overall cancer risk, and the existing evidence lacks statistical power to draw a convincing conclusion. METHODS Herein we performed an update meta-analysis to re-evaluate the association between rs2736098 polymorphism and the risk of overall cancer with all the case-control studies published before March 2015 according to PubMed and Embase databases. RESULTS A total of 19 case-control studies were included in this analysis. We found that variant genotypes of rs2736098 (GA/AA) were significantly associated with an increased risk of overall cancer (GA/AA vs GG: OR=1.14; 95% CI=1.04-1.25). Additionally, the association was more significant in Asians (OR=1.20; 95% CI=1.07-1.34), while in subsequent analyses stratified by cancer type, the variant rs2736098 was definitely associated with increased lung cancer (OR=1.18; 95% CI=1.07-1.29) and hepatocellular carcinoma risk (OR=1.38; 95% CI=1.20-1.59). CONCLUSION These findings provided further evidence that TERT rs2736098 variant may modify the susceptibility to cancer.
File Format	PDF HTM / HTML
PubMed reference number	27273963
Journal	Medline
Volume Number	21
Issue Number	2
Alternate Webpage(s)	https://www.jbuon.com/pdfs/JBUON-21-2-29.pdf
Journal	Journal of B.U.ON. : official journal of the Balkan Union of Oncology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article