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Rapidly progressive stage IVB mycosis fungoides treated with low-dose total skin electron beam therapy
| Content Provider | Semantic Scholar |
|---|---|
| Author | Chowdhary, Mudit Kabbani, Ahmad A. Rimtepathip, Parin P. Cole, D. Austin Cohen, David Jacques |
| Copyright Year | 2015 |
| Abstract | Mycosis fungoides (MF) is the most common subtype of primary cutaneous T-cell lymphoma. Normally, MF has an indolent course although patients can progress to an advanced disease state (stages IIB-IVB). Advanced-stage disease is typically aggressive, leaving patients with debilitating symptoms and a decreased quality of life. Moreover, advanced-stage MF often proves refractory to therapy and carries a very poor prognosis. Total skin electron beam (TSEB) therapy is a well-established and successful treatment for early stage MF; however, its efficacy dramatically decreases with advanced-stage disease. In fact, TSEB in advanced-stage MF is generally considered to be palliative. Current consensus guidelines recommend a dose of 30-36 Gy to be delivered in 8-10 weeks; however, limited studies exist to determine the ideal treatment in Stage IV MF. Herein, we describe a case of a 50-year-old male who developed rapidly progressive stage IVB (T3N3M1B0) MF and was treated with low-dose (24 Gy) TSEB over 8 weeks. The patient was not treated with any systemic therapy before starting TSEB due to the widespread nature and the speed of disease progression. Remarkably, our patient showed nearly complete (95%) response of his MF with no apparent side effects from radiation. Furthermore, he has remained in remission over 4 years, requiring only a small boost to a few "shadowed" areas. Our case illustrates the benefit of using TSEB in stage IV MF. Additionally, our experience shows that low-dose TSEB can occasionally be efficacious in stage IV disease. |
| Starting Page | 1597 |
| Ending Page | 1601 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.dovepress.com/getfile.php?fileID=25747 |
| Alternate Webpage(s) | http://ftp.ncbi.nlm.nih.gov/pub/pmc/e2/73/ott-8-1597.PMC4493984.pdf |
| PubMed reference number | 4493984 |
| Alternate Webpage(s) | https://doi.org/10.2147/OTT.S87219 |
| DOI | 10.2147/ott.s87219 |
| Journal | OncoTargets and therapy |
| Volume Number | 8 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Cancer Remission Gray unit of radiation dose Limited stage (cancer stage) Lymphoma, T-Cell, Cutaneous Mycoses Mycosis Fungoides Patients Progressive Disease Skin Neoplasms Stage 4B Stage level 4 T-Cell Lymphoma electron beam stage IV childhood Hodgkin's lymphoma systemic therapy |
| Content Type | Text |
| Resource Type | Article |
