Loading...
Please wait, while we are loading the content...
Similar Documents
Association of serum sex steroid receptor bioactivity and sex steroid hormones with breast cancer risk in postmenopausal women
| Content Provider | Semantic Scholar |
|---|---|
| Author | Fourkala, Evangelia-Ourania Zaikin, Alexey Burnell, Matthew Grant Gentry-Maharaj, Aleksandra Ford, Jeremy W. Gunu, Richard Soromani, Christina Hasenbrink, Guido Jacobs, Ian Dawnay, Anne Widschwendter, Martin Lichtenberg-Fraté, Hella Menon, Usha |
| Copyright Year | 2012 |
| Abstract | Postmenopausal women with elevated serum sex steroids have an increased risk of breast cancer. Most of this risk is believed to be exerted through binding of the sex steroids to their receptors. For the first time, we investigate the association of estrogen receptor (ER) and androgen receptor (AR) serum bioactivity (SB) in addition to hormone levels in samples from women with breast cancer collected before diagnosis. Two hundred postmenopausal women participating in the UK Collaborative Trial of Ovarian Cancer Screening who developed ER-positive breast cancer 0.6-5 years after sample donation were identified and matched to 400 controls. ER and AR bioassays were used to measure ERα, ERβ, and AR SB. Androgen and estrogen levels were measured with immunoassays. Subjects were classified according to quintiles of the respective marker among controls and the associations between SB and hormones with breast cancer risk were determined by logistic regression analysis. ERα and ERβ SB were significantly higher before diagnosis compared with controls, while estrogens showed no difference. Women had a twofold increased breast cancer risk if ERα SB (odds ratio (OR), 2.114; 95% confidence interval (CI), 1.050-4.425; P=0.040) was in the top quintile >2 years before diagnosis or estrone (OR, 2.205; 95% CI, 1.104-4.586; P=0.029) was in the top quintile <2 years before diagnosis. AR showed no significant association with breast cancer while androstenedione (OR, 3.187; 95% CI, 1.738-6.044; P=0.0003) and testosterone (OR, 2.145; 95% CI, 1.256-3.712; P=0.006) were significantly higher compared with controls and showed a strong association with an almost threefold increased breast cancer risk independent of time to diagnosis. This study provides further evidence on the association of androgens and estrogens with breast cancer. In addition, it reports that high ER but not AR SB is associated with increased breast risk >2 years before diagnosis. |
| Starting Page | 137 |
| Ending Page | 147 |
| Page Count | 11 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 22199143v1 |
| DOI | 10.1530/erc-11-0310 |
| Journal | Endocrine-related cancer |
| Volume Number | 19 |
| Alternate Webpage(s) | https://erc.bioscientifica.com/downloadpdf/journals/erc/19/2/137.pdf |
| Alternate Webpage(s) | http://www.ucl.ac.uk/~rmjbale/PAPERS_OWN/79_2012_Fourkala_Zaikin.pdf |
| Alternate Webpage(s) | http://ftp.ncbi.nlm.nih.gov/pub/pmc/6d/0e/ERC110310.PMC3322660.pdf |
| Alternate Webpage(s) | https://doi.org/10.1530/ERC-11-0310 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Androgen Receptor Androgens Androstenedione Biological Assay Classification Confidence Intervals Estrogen Receptors Estrogens Estrone Gonadal Steroid Hormones Immunoassay method Mammary Neoplasms Mental association Receptors, Steroid Steroid hormone Steroids Testosterone estrogen receptor alpha, human ovarian neoplasm |
| Content Type | Text |
| Resource Type | Article |
