NDLI: Transplantation of wheat germ agglutinin-positive hematopoietic cells to prevent or induce systemic autoimmune disease.

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Transplantation of wheat germ agglutinin-positive hematopoietic cells to prevent or induce systemic autoimmune disease.

Content Provider	Semantic Scholar
Author	Sardiña, E. E. Sugiura, Kikuya Ikehara, Susumu Good, Robert Alan
Copyright Year	1991
Abstract	Hematopoietic stem cell defects are thought to be involved in the etiopathogenesis of systemic autoimmune disease. Positively selected, stem cell-enriched populations of wheat germ agglutinin-positive (WGA+) low-density bone marrow and fetal liver cells from normal and autoimmune-prone mice were used to determine whether reciprocal transplantation of stem cells between normal and autoimmune-prone mice inhibits or causes development of autoimmune disease. NZB recipients of DBA/2 stem cell populations analyzed greater than 100 days after bone marrow or fetal liver cell transplantation showed decreased levels of anti-DNA antibodies and decreased glomerular lesions when compared with nontreated NZB mice or NZB recipients of NZB stem cell preparations. Female DBA/2 recipients of WGA+ NZB bone marrow cell or fetal liver cell transplants exhibited elevated serum autoantibody levels and developed glomerular lesions characteristic of NZB mice when analyzed greater than 100 days after transplantation. These pathological disturbances were not observed in DBA/2 recipients of DBA/2 stem cell preparations. The data indicate that WGA+ stem cells from autoimmune-prone NZB mice contain the genetic defects responsible for the development of systemic autoimmune disease.
Starting Page	2307
Ending Page	2313
Page Count	7
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.pnas.org/content/88/8/3218.full.pdf
PubMed reference number	1673029v1
Volume Number	88
Issue Number	8
Journal	Proceedings of the National Academy of Sciences of the United States of America
Language	English
Access Restriction	Open
Subject Keyword	Agglutinins Autoantibodies Autoimmune Diseases Bone Marrow Cells Cell Transplantation Fetal Liver Hepatocyte Liver diseases Mice, Inbred DBA Mice, Inbred NZB Stem cells Transplanted tissue childhood central nervous system germ cell tumor
Content Type	Text
Resource Type	Article

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