Severe aplastic anemia: a prospective study of the effect of early marrow transplantation on acute mortality.

Content Provider	Semantic Scholar
Author	Camitta, Bruce M. Thomas, Eric D. Nathan, D. Grubaugh Santos, Grau Gordon-Smith, E. C. Gale, Robert Peter Rappeport, Joel M. Storb, Rainer
Copyright Year	1976
Abstract	A prospective randomized trial of therapy for severe aplastic anemia was designed to compare early bone marrow transplantation with conventional treatments. All patients with a sibling matched at the major histocompatibility region were transplanted. Transplantation was performed with 17-100 (median 33) days of original diagnosis. Conventional treatments included transfusion support with or without androgens. Twenty-four of 36 patients intered on the transplant arm are alive after 4-20 (median 9) mo with full marrow reconstitution. Only two are limited by chronic graft-versus-host disease. In contrast only 12 of 31 conventionally treated patients are alive. Six of these survivors have improved, five incompletely. The 19 nontransplant deaths have occurred within 1-11 (median 3) mo of diagnosis. Compared to nontransplant regimens, early transplantation more effectively restores normal marrow function and decreases the acute mortality of severe marrow aplasia (p = 0.006). Pending longer follow-up, early marrow transplantation appears to be the most effective available treatment for severe aplastic anemia.
Starting Page	63
Ending Page	70
Page Count	8
File Format	PDF HTM / HTML
DOI	10.1182/blood.V48.1.63.63
PubMed reference number	779871
Journal	Medline
Volume Number	48
Issue Number	1
Alternate Webpage(s)	http://www.bloodjournal.org/content/bloodjournal/48/1/63.full.pdf?sso-checked=true
Alternate Webpage(s)	https://doi.org/10.1182/blood.V48.1.63.63
Journal	Blood
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article