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Vascular Wall Imaging of Unruptured Cerebral Aneurysms with a Hybrid of Opposite-Contrast MR Angiography.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Matsushige, Toshinori Akiyama, Y. Okazaki, T. Shinagawa, Katsuhiro Ichinose, Nobuhiko Awai, Kazuo Kurisu, Kojiro |
| Copyright Year | 2015 |
| Abstract | BACKGROUND AND PURPOSE Inflammation and degeneration of the intracranial saccular aneurysm wall play a major role in aneurysm formation, development and subsequent rupture. The aim of this study was to characterize the walls of unruptured intracranial aneurysms by using a hybrid of opposite-contrast MRA at 3T. MATERIALS AND METHODS Fourteen consecutive patients with 17 unruptured intracranial aneurysms who initially underwent clipping surgery were prospectively evaluated. All aneurysms were scanned preoperatively by using a hybrid of opposite-contrast MRA in 3T high-resolution MR imaging. We classified intraoperative findings of atherosclerotic plaques in the aneurysms into 3 grades: grade A (major plaques), grade B (minor plaques), and grade C (no plaques). The contrast ratio of the high-intensity area was also measured relative to the background low-intensity area inside the carotid artery. RESULTS Findings from preoperative plaque imaging of the aneurysm corresponded to the intraoperative findings in 15 of 16 aneurysms (excluding 1 that was impossible to visualize in its entirety due to anatomic reasons). Overall sensitivity and specificity of the hybrid of opposite-contrast MRA were 88.9% and 100%, respectively. During the operation, 4 aneurysms were classified as grade A; 5, as grade B; and 7, as grade C. The means of the contrast ratio for grades A, B, and C were 0.72 ± 0.03, 0.34 ± 0.30, and -0.02 ± 0.09, respectively. CONCLUSIONS The hybrid of opposite-contrast MRA can detect visible atherosclerotic plaques in the unruptured aneurysm wall, and the contrast ratio in intracranial aneurysms correlated with their presence and extent. A study including a larger series is needed to validate the diagnostic potential of this imaging technique. |
| File Format | PDF HTM / HTML |
| DOI | 10.3174/ajnr.A4318 |
| PubMed reference number | 25929881 |
| Journal | Medline |
| Volume Number | 36 |
| Issue Number | 8 |
| Alternate Webpage(s) | http://www.ajnr.org/content/ajnr/early/2015/04/30/ajnr.A4318.full.pdf |
| Alternate Webpage(s) | https://doi.org/10.3174/ajnr.A4318 |
| Journal | AJNR. American journal of neuroradiology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
