NDLI: Synthesis and biological evaluation of 8-substituted berberine derivatives as novel anti-mycobacterial agents

Content Provider	Semantic Scholar
Author	Wang, Yan-Xiang Fu, Hai-Gen Li, Ying-Hong Jiang, Jian-Dong Song, Dan-Qing
Copyright Year	2012
Abstract	Abstract Tuberculosis (TB) is a disease which kills two million people every year and infects over one-third of the world′s population. Eighteen new 8-substituted berberine derivatives were synthesized and evaluated for their anti-mycobacterial activities against Mycobacterium tuberculosis ( M. tuberculosis ) strain H 37 Rv. Among these compounds, compound 6i was the most effective antitubercular agent with an MIC of 1.0 μg/mL. Most importantly, compound 6i also exhibited a potent effect against clinically isolated rifampicin- and isoniazid-resistant M. tuberculosis strains, suggesting a different mode of action from the current drugs. Therefore, it shows potential for the development of new anti-TB agents.
Starting Page	581
Ending Page	587
Page Count	7
File Format	PDF HTM / HTML
DOI	10.1016/j.apsb.2012.10.008
Volume Number	2
Alternate Webpage(s)	https://core.ac.uk/download/pdf/82389512.pdf
Alternate Webpage(s)	https://doi.org/10.1016/j.apsb.2012.10.008
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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