NDLI: Variant of hepatitis B virus with primary resistance to adefovir.

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Variant of hepatitis B virus with primary resistance to adefovir.

Content Provider	Semantic Scholar
Author	Schildgen, Oliver Sirma, Hueseyin Funk, Anneke Olotu, Cynthia Wend, Ulrike C. Hartmann, Handledare Elke Helm, Martin Rockstroh, Jürgen K. Willems, Wulf R. Will, H. Gerlich, Wolfram H.
Copyright Year	2006
Abstract	The reverse-transcriptase inhibitor lamivudine (Zeffix, GlaxoSmithKline) is often used to treat chronic infection with hepatitis B virus (HBV) until resistance develops. Treatment may then be switched to the reverse-transcriptase inhibitor adefovir (Hepsera, Gilead), which has a lower frequency of resistance. Here, we describe three cases of primary adefovir resistance that were sensitive to tenofovir (Viread, Gilead). All three cases involved a rare HBV variant with a valine at position 233 of the reverse-transcriptase domain instead of isoleucine (rtI233V), as in the wild-type virus. This HBV variant also displayed resistance to adefovir and sensitivity to tenofovir in vitro.
Starting Page	3103
Ending Page	3112
Page Count	10
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.gastro-praxis-herne.de/fileadmin/download/New%20England%20Journal%20of%20Medicine.pdf
Alternate Webpage(s)	http://hub.hku.hk/bitstream/10722/57524/1/135303.pdf
PubMed reference number	16641397v1
Volume Number	354
Issue Number	17
Journal	The New England journal of medicine
Language	English
Access Restriction	Open
Subject Keyword	Chemical and Drug Induced Liver Injury Hepatitis B Virus Herpesvirus 1, Cercopithecine In Vitro [Publication Type] Isoleucine Lamivudine SmithKline Beecham Tenofovir Valine adefovir
Content Type	Text
Resource Type	Article

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